Esophageal reflux, commonly known as gastroesophageal reflux disease (GERD), is a chronic condition where stomach contents flow back into the esophagus, causing symptoms like heartburn, regurgitation and, in severe cases, damage to the esophageal lining. Conventional treatment options, including proton pump inhibitors (PPIs) and H2 receptor antagonists, focus on reducing stomach acid production to alleviate symptoms and prevent complications. However, prolonged use of these medications is associated with potential side effects, such as impaired nutrient absorption, an increased risk of fractures, chronic kidney disease and changes in gut microbiota, prompting many patients to consider alternative management options.
Metabolic syndrome, also known as syndrome X, is not a single disease but a collection of risk factors that occur together. Individuals with metabolic syndrome are at a higher risk of experiencing a range of health complications, including cardiovascular disease, type 2 diabetes, non-alcoholic fatty liver disease and certain types of cancer. The incidence of metabolic syndrome has been increasing over the past few decades and is predicted to continue escalating in the coming years.
The human body is a complex and interconnected system, where various organs and systems communicate with each other to maintain homeostasis. An area of research that has gained attention in recent years is the exploration of the GI-Skin-Brain axis. This axis refers to the bidirectional communication between the gastrointestinal (GI) system, the skin, and the brain.
