Speaker: Kevin Spelman. The endogenous cannabinoids are ubiquitous in mammalian physiology and affect many tissues and pathways including immune function,metabolism and neurological tone. Curiously, most medical schools still do not cover the endocannabinoid system, despite its involvement in a variety of chronic diseases including cancer, metabolic disorders, immunological issues and mental illness. We review the role of the endocannabinoid system and discuss various medicinal plant species that impact these common pathways.